High Resolution Mass Spectrometry

Instrument: Thermo Exactive Plus Orbitrap Mass Spectrometer with a Dionex UltiMate 3000 Quaternary RSLCnano System

High resolution mass spectrometry uses instruments capable of measuring the mass of chemicals to the 3rd of 4th decimal place, i.e. highly accurately. This accurate mass measurement, along with the pattern of isotopes, allows the exact chemical composition of small chemicals to be deduced with high confidence and even narrows down the elemental composition of biological molecules to a small range of potential formulas. Combined with fragmentation of the chemicals and accurate mass measurement of the pieces, HRMS is invaluable to prove the identity of a chemical.
Technical Detail
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